Anti-dormant mycobacterial activity of Melissa officinalis L. (Lemon balm).

Mycobacterium tuberculosis is one of the most common causes morbidity and mortality among adults who have tested HIV-positive or those living in poverty. One major reasons for need extended chemotherapeutic regimens widespread epidemicity that causative agent, M. tuberculosis, has ability to be a dormant state. Therefore, there an urgent new lead compounds are effective against both its active states. In this study, we investigated anti-mycobacterial activity total ethanol extract fractions Melissa officinalis L. (Lemon balm) under actively growing dormancy inducing conditions. As result, exhibited antimicrobial states smegmatis bovis BCG with Minimum Inhibitory Concentration (MIC) values ranging from 12.5 µg/mL 50 µg/mL. Among fractions, n-hexane fraction showed ideal (MIC = 6.25 µg/mL). addition, also µg/mL), while moderate µg/mL) was observed state BCG.